Acetic Anhydride → 5,6-Diacetoxy-2-acetylindoline

HRID 704461ノート

反応式

HRID 704461 の反応式
Br.[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[OH:12])[CH2:8][NH:7][CH2:6]2.C(O[C:17](=[O:19])[CH3:18])(=O)C>N1C=CC=CC=1>[C:3]([O:12][C:11]1[CH:10]=[C:9]2[C:8](=[CH:4][C:3]=1[O:2][C:11](=[O:12])[CH3:10])[NH:7][CH:6]([C:17](=[O:19])[CH3:18])[CH2:5]2)(=[O:2])[CH3:4]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 200743492,3-dihydro-1H-isoindole-5,6-diol hydrobromide

生成物 1

HCID 200743545,6-Diacetoxy-2-acetylindoline収率 89%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

500 mg (2.15 mmol) of 5,6-dihydroxyisoindoline hydrobromide was dissolved in 2.5 ml of pyridine, and 2.5 ml of acetic anhydride was added thereto at room temperature. The mixture was stirred at the same temperature for 30 minutes, and then excess pyridine and acetic anhydride were distilled off under reduced pressure. Ethyl acetate was added to the residue, and insoluble matters were filtered off. The filtrate was concentrated under reduced pressure, and the crystalline residue was washed with ethyl ether to obtain 532 mg (yield: 89.0%) of the above identified compound.

後処理

  1. customat room temperature
  2. distillationexcess pyridine and acetic anhydride were distilled off under reduced pressure
  3. additionEthyl acetate was added to the residue, and insoluble matters
  4. filtrationwere filtered off
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. washthe crystalline residue was washed with ethyl ether
  7. customto obtain 532 mg (yield: 89.0%) of the

出典と根拠

ORDレコード
ord-1ad1245ddf7144329cf86870edd6fbe9
出典データセット
uspto-grants-1991_01
特許番号
US04987235

反応ノート

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