Diethylamine → 3-Bromo-n,n-diethylpropanamide

HRID 70447

反応式

HRID 70447 の反応式
[Br:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[CH2:7]([NH:9][CH2:10][CH3:11])[CH3:8]>C1COCC1>[Br:1][CH2:2][CH2:3][C:4]([N:9]([CH2:10][CH3:11])[CH2:7][CH3:8])=[O:5]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 84944Propanoyl chloride, 3-bromo-

生成物 1

HCID 2261123-Bromo-n,n-diethylpropanamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A mixture of 3-bromopropanoyl chloride (1.0 g, 5.8 mmol) and diethylamine (1.9 g, 26 mmol) in THF (20 ml) was stirred at 0° C. for 30 min, the resulting white solid was filtered and the filtrate was concentrated to give a crude oil which was used in the next reaction without further purification.

後処理

  1. filtrationthe resulting white solid was filtered
  2. concentrationthe filtrate was concentrated
  3. customto give a crude oil which
  4. customwas used in the next reaction without further purification

出典と根拠

ORDレコード
ord-bb963a68e9dd4b3f84fe5e6051568428
出典データセット
uspto-grants-2014_09
特許番号
US08822530B2

関連ノート

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