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Dichloromethane → 1-(2-Methylphenyl)-6-methylpyrrolo[3,2-c]cinnoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 1-(2-Methylphenyl)-6-methyl-2,3-dihydropyrrolo [3,2-c]cinnoline | HCID 20072757 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | 1-(2-Methylphenyl)-6-methylpyrrolo[3,2-c]cinnoline | HCID 20072754 | — |
反応手順
To a refluxing slurry of 10% Pd/C (0.4 g) in diphenyl ether (20 ml) was added 1-(2-methylphenyl)-6-methyl-2,3-dihydropyrrolo [3,2-c]cinnoline (1.25 g, 0.0045 mol). After 0.5 hour at reflux temperature the reaction mixture was cooled, diluted with chloroform and the catalyst was filtered off over hyflo. The product was isolated by column chromatography using dichloromethane (11) then chloroform. The oil obtained was crystallized from ethyl acetate, 0.42 g, m.p. 105-106°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04988695 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-c6ddbe0469dc4c2e99913a8c9ed2a0f2 |
| 出典メモ | uspto-grants-1991_01 |