反应详情

To a refluxing slurry of 10% Pd/C (0.4 g) in diphenyl ether (20 ml) was added 1-(2-methylphenyl)-6-methyl-2,3-dihydropyrrolo [3,2-c]cinnoline (1.25 g, 0.0045 mol). After 0.5 hour at reflux temperature the reaction mixture was cooled, diluted with chloroform and the catalyst was filtered off over hyflo. The product was isolated by column chromatography using dichloromethane (11) then chloroform. The oil obtained was crystallized from ethyl acetate, 0.42 g, m.p. 105-106°.

1. temperatureAfter 0.5 hour at reflux temperature the reaction mixture
2. temperaturewas cooled
3. filtrationthe catalyst was filtered off over hyflo
4. customThe product was isolated by column chromatography
5. customThe oil obtained
6. customwas crystallized from ethyl acetate, 0.42 g, m.p. 105-106°