Pyridine → 1-[2-(2,3-Dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride

HRID 704627ノート

反応式

HRID 704627 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]2([CH3:16])[CH3:15])=[O:4].[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl-:1].[CH3:15][C:8]1([CH3:16])[C:7]2[C:11](=[CH:12][CH:13]=[C:5]([C:3](=[O:4])[CH2:2][N+:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:6]=2)[NH:10][C:9]1=[O:14]

参加物

3

反応物 2

HCID 1049PyridineHCID 107523795-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

生成物 1

HCID 200728801-[2-(2,3-Dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride

反応条件

温度
85 °C

実験手順

To 5-chloroacetyl-2,3-dihydro-3,3-dimethylindol-2-one (35 g) was added pyridine (140 ml) and the mixture was stirred to 1.6 hours at 85° C. After the mixture was cooled to ambient temperature, the crystal was collected by filtration and washed with pyridine and diethyl ether successively to give 1-[2-(2,3-dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride (44.6 g).

後処理

  1. temperatureAfter the mixture was cooled to ambient temperature
  2. filtrationthe crystal was collected by filtration
  3. washwashed with pyridine and diethyl ether successively

出典と根拠

ORDレコード
ord-e335379dc56f4bdd96ff1fd879934fbf
出典データセット
uspto-grants-1991_01
特許番号
US04988698

反応ノート

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