Hydrochloric Acid → 3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid
反応式
[OH-:1].[Na+].[Cl-].[CH3:4][C:5]1([CH3:24])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14](=[O:22])C[N+]3C=CC=CC=3)[CH:12]=2)[NH:7][C:6]1=[O:23].Cl>O>[CH3:24][C:5]1([CH3:4])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([OH:22])=[O:1])[CH:12]=2)[NH:7][C:6]1=[O:23]参加物
5
実験手順
To a solution of sodium hydroxide (14 g) in water (480 ml) was added 1-[2-(2,3-dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride (44.3 g) and the mixture was stirred for 1.5 hours at 80° to 85° C. After cooling, the reaction mixture was acidified with conc. hydrochloric acid. The residual crystal was collected by filtration, washed with water and dried to give 2,3-dihydro-3,3-dimethyl-2-oxoindole-5-carboxylic acid (21 g).
後処理
- temperatureAfter cooling
- filtrationThe residual crystal was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-0e2bb4ff98e8454c913961c77c3ad3d0
- 出典データセット
- uspto-grants-1991_01
- 特許番号
- US04988698
反応ノート
読み込み中…