Furfurylamine → HCID 15058198、化合物

HRID 704659ノート

反応式

HRID 704659 の反応式
[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([CH2:16][OH:17])O[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:24]1[CH:28]=[C:27]([CH2:29][NH2:30])[O:26][CH:25]=1>CO.C(Cl)(Cl)Cl>[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([CH2:16][OH:17])[N:30]([CH2:29][C:27]3[O:26][CH:25]=[CH:24][CH:28]=3)[CH:10]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 3438FurfurylamineHCID 143063875-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one

生成物 1

HCID 15058198HCID 15058198、化合物収率 70.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6212Chloroform溶媒

実験手順

To a solution of 3.083 g of 3-diphenylmethoxy-6-hydroxymethyl-4-pyrone in 50 ml of methanol is added 7.645 g of 2-furfurylamine at room temperature, and the mixture is stirred for 4 days. The reaction mixture is condensed under reduced pressure, and the resulting residue is dissolved in 600 ml of chloroform. The organic solution is washed with water, a saturated aqueous potassium hydrogen sulfate solution in this sequence, dried over anhydrous magnesium sulfate and condensed under reduced pressure. The resulting crystal is collected by filtration, washed with a small amount of chloroform and dried under reduced pressure to give the title compound (2.72 g).

後処理

  1. customcondensed under reduced pressure
  2. washThe organic solution is washed with water
  3. dry with materiala saturated aqueous potassium hydrogen sulfate solution in this sequence, dried over anhydrous magnesium sulfate and condensed under reduced pressure
  4. filtrationThe resulting crystal is collected by filtration
  5. washwashed with a small amount of chloroform
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-fe4d0e4cc2d84ddb8fe5a06316cda6d5
出典データセット
uspto-grants-1991_01
特許番号
US04988686

反応ノート

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