Sodium Chloride → 8-Pyrrolidinyl-5,6,7,8-tetrahydroquinoline

HRID 704854ノート

反応式

HRID 704854 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH:7]1[C:16]2[N:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9][CH2:8]1.[Cl-].[Na+]>O>[N:1]1([CH:7]2[C:16]3[N:15]=[CH:14][CH:13]=[CH:12][C:11]=3[CH2:10][CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 31268PyrrolidineHCID 137121808-Chloro-5,6,7,8-tetrahydroquinoline

生成物 1

HCID 139833798-Pyrrolidinyl-5,6,7,8-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Over a period of 7 minutes with stirring and while allowing it to heat up, 50 ml of pyrrolidine were added to a solution of 20 g of 8-chloro-5,6,7,8-tetrahydroquinoline in 50 ml of water. The temperature reached 57° C. at the end of the introduction and stirring was continued for 1 hour at this temperature. The temperature was then allowed to return to 20° C. and the reaction medium was saturated with sodium chloride and then was extracted with ether. The combined organic phases were dried and the solvents were eliminated under reduced pressure to obtain 20.22 g or 8-pyrrolidinyl-5,6,7,8-tetrahydroquinoline in the form of an oil.

後処理

  1. temperatureto heat up
  2. customreached 57° C. at the end of the introduction
  3. stirringstirring
  4. waitwas continued for 1 hour at this temperature
  5. customto return to 20° C.
  6. extractionwas extracted with ether
  7. customThe combined organic phases were dried

出典と根拠

ORDレコード
ord-fc1665e16535462bb4840f3eb7ec95b1
出典データセット
uspto-grants-1991_01
特許番号
US04988810

反応ノート

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