Dimethylamine → N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine

HRID 704856ノート

反応式

HRID 704856 の反応式
Cl.Cl[CH:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1.[CH3:13][NH:14][CH3:15].[Cl-].[Na+].[OH-].[Na+]>>[CH3:13][N:14]([CH3:15])[CH:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1

参加物

5

反応物 4

HCID 674DimethylamineHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 137121818-Chloro-5,6,7,8-tetrahydroquinoline hydrochloride

生成物 1

HCID 20073468N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine

実験手順

4.08 g of 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride of Example 1 were mixed with stirring for 75 minutes in 20 ml of a 40% aqueous solution of dimethylamine and the mixture was heated for 1 hour at 65° C. ±2° C., then allowed to cool to ambient temperature. The reaction medium was saturated with sodium chloride and 0.3 ml of 2N sodium hydroxide were added. After extracting with ether, the extracts were washed with water, dried, and the solvent was eliminated under reduced pressure to obtain 3.35 g of N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine which was used as is for the following step.

後処理

  1. temperaturethe mixture was heated for 1 hour at 65° C. ±2° C.
  2. additionwere added
  3. extractionAfter extracting with ether
  4. washthe extracts were washed with water
  5. customdried

出典と根拠

ORDレコード
ord-dd037220148844be856ca320151b5acd
出典データセット
uspto-grants-1991_01
特許番号
US04988810

反応ノート

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