Water → 2-Bromo-6-iodo-3-propoxypyridine

HRID 70546

反応式

HRID 70546 の反応式
C(=O)([O-])[O-].[K+].[K+].[CH2:7](I)[CH2:8][CH3:9].[Br:11][C:12]1[C:17]([OH:18])=[CH:16][CH:15]=[C:14]([I:19])[N:13]=1.O>CN(C)C=O>[Br:11][C:12]1[C:17]([O:18][CH2:7][CH2:8][CH3:9])=[CH:16][CH:15]=[C:14]([I:19])[N:13]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 109794792-Bromo-6-iodopyridin-3-ol

生成物 1

HCID 866580042-Bromo-6-iodo-3-propoxypyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Potassium carbonate (1.38 g) and n-propyl iodide (1.13 g) were added to a solution of 2-bromo-6-iodopyridin-3-ol (1.0 g, described in WO 2007088996) in N,N-dimethylformamide (10 mL), and the mixture was stirred at room temperature for two hours. The reaction solution was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and filtered, after which the solvent was evaporated under reduced pressure to give 2-bromo-6-iodo-3-propoxypyridine as a crude product.

後処理

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customafter which the solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2d65931bbfa7416b8739f813d3395e7f
出典データセット
uspto-grants-2014_09
特許番号
US08822503B2

関連ノート

読み込み中…