Thionyl Chloride → 5-Chloro-2-iodobenzoyl chloride
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].O=S(Cl)[Cl:14]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]参加物
4
反応条件
- 温度
- 100 °C
実験手順
To a solution of 5-chloro-2-iodobenzoic acid (3.0 g, 10.6 mmol) in toluene (150 mL), SOCl2 (7.75 mL, 106 mmol) was added and the mixture was heated at 100° C. for 3 hours. The solvent was concentrated in vacuum and the residue was co-evaporated from toluene twice to give the title compound as a grey solid. Yield (3.2 g, 100%)
後処理
- concentrationThe solvent was concentrated in vacuum
出典と根拠
- ORDレコード
- ord-1c8449d22bf54d2cabf83b2c45026c65
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09174977B2
反応ノート
読み込み中…