methyl 3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoate → Methyl 3-(1-methyl-1H-pyrazol-4-yl)propanoate
反応式
[CH3:1][N:2]1[CH:6]=[C:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10])[CH:4]=[N:3]1>C(O)C.[Pd]>[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:4]=[N:3]1参加物
4
反応条件
- 温度
- 40 °C
実験手順
To a solution of methyl ((E)-Methyl 3-(1-methyl-1H-pyrazol-4-yl)acrylate (18 g, 108 mmol) in ethanol (300 ml) was added Pd/C (4 g, 37.6 mmol) at room temperature. The reaction mixture was stirred at 40° C. for 12 h under hydrogen. The reaction mixture was cooled to room temperature, then the solid was removed by filtration. The filtrate was concentrated in vacuo to give the title compound as colorless oil (17.8 g, 80% yield). LCMS: rt=1.27 min, [M+H+]=169
後処理
- temperatureThe reaction mixture was cooled to room temperature
- customthe solid was removed by filtration
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-947543c1915b4dbba49ab722cdfaa869
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09174968B2
反応ノート
読み込み中…