HCID 89524899、化合物 → HCID 89524967、化合物

HRID 706348ノート

反応式

HRID 706348 の反応式
I[C:2]1[O:3][CH:4]=[C:5]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[N:6]=1>CCO.[Pd]>[O:3]1[CH:4]=[C:5]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[N:6]=[CH:2]1

参加物

4

反応物 1

HCID 89524899HCID 89524899、化合物

生成物 1

HCID 89524967HCID 89524967、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Hydrogenolysis of the tert-butyl 2-(2-iodooxazol-4-yl)benzylcarbamate was performed using H-Cube, 10% Pd/C, full H2 Mode, at 25° in EtOH. Following completion the reaction was concentrated and the residue was purified via Biotage (0% to 10% gradient; EtOAc:Hex; 50 g-HP-silica gel column). Obtained 200 mg of tert-butyl 2-(oxazol-4-yl)benzylcarbamate. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.47 (s, 9H) 4.39 (s, 2H) 7.36 (ddd, J=7.26, 5.37, 1.77 Hz, 2H) 7.48-7.65 (m, 2H) 7.89 (d, J=1.01 Hz, 1H) 8.00 (s, 1H); MS[MH]+=275.2

後処理

  1. customat 25°
  2. concentrationwas concentrated
  3. customthe residue was purified via Biotage (0% to 10% gradient; EtOAc:Hex; 50 g-HP-silica gel column)

出典と根拠

ORDレコード
ord-69b44956812d4f778955e8333f68479d
出典データセット
uspto-grants-2015_11
特許番号
US09174984B2

反応ノート

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