ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Formamide → (5R)-5-{(E)-2-(4-tert-butylphenyl)-2-[5-(dimethylamino)-6-methoxypyridin-2-yl]ethenyl}pyrrolidin-2-one

HRID 70649
ノート
印刷プレビュー

反応式

HRID 70649 の反応式
[CH:1]([NH2:3])=O.N[C:5]1[CH:6]=[CH:7][C:8](/[C:13](/[C:21]2[CH:26]=[CH:25][C:24]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:23][CH:22]=2)=[CH:14]/[C@@H:15]2[NH:19]C(=O)C[CH2:16]2)=[N:9][C:10]=1OC.C(O[BH-](O[C:41](=[O:43])[CH3:42])OC(=O)C)(=O)C.[Na+].[C:45](=[O:48])(O)[O-].[Na+].[C:50](#N)C>>[C:27]([C:24]1[CH:25]=[CH:26][C:21](/[C:13](/[C:8]2[CH:7]=[CH:6][C:5]([N:3]([CH3:1])[CH3:50])=[C:10]([O:48][CH3:45])[N:9]=2)=[CH:14]\[C@@H:15]2[NH:19][C:41](=[O:43])[CH2:42][CH2:16]2)=[CH:22][CH:23]=1)([CH3:28])([CH3:29])[CH3:30]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 5

HCID 713FormamideHCID 6342AcetonitrileHCID 516892Sodium BicarbonateHCID 5049666Sodium triacetoxyborohydrideHCID 67399550HCID 67399550、化合物

生成物 1

HCID 67400002(5R)-5-{(E)-2-(4-tert-butylphenyl)-2-[5-(dimethylamino)-6-methoxypyridin-2-yl]ethenyl}pyrrolidin-2-one

実験手順

A 37% formamide solution (40 μL) was added to a solution of (5R)-5-[(E)-2-(5-amino-6-methoxypyridin-2-yl)-2-(4-tert-butylphenyl)ethenyl]pyrrolidin-2-one obtained in Example 4-173(2) (40 mg) in acetonitrile (2 mL) under ice-cooling, followed by stirring for 10 minutes. Sodium triacetoxyborohydride (120 mg) was added thereto and the mixture was stirred at room temperature for 15 hours. Saturated aqueous sodium bicarbonate was added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure to give (5R)-5-{(E)-2-(4-tert-butylphenyl)-2-[5-(dimethylamino)-6-methoxypyridin-2-yl]ethenyl}pyrrolidin-2-one as a yellow oil (41 mg).

後処理

  1. temperaturecooling
  2. stirringthe mixture was stirred at room temperature for 15 hours
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customafter which the solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-237b59d9315147ae833ae00b60489882
出典データセット
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08822503B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート