Ethyl 6-(prop-1-en-2-yl)picolinate → Ethyl 6-isopropylpicolinate

HRID 706533ノート

反応式

HRID 706533 の反応式
[CH2:1]=[C:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)[CH3:3]>CCO.[Pd]>[CH:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:1]

参加物

4

反応物 1

HCID 67974687Ethyl 6-(prop-1-en-2-yl)picolinate

生成物 1

HCID 67974663Ethyl 6-isopropylpicolinate収率 93.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen three times and then with hydrogen three times. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with N2, filtered through Celite and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give 4.36 g (93%) of ethyl 6-isopropylpicolinate.

後処理

  1. customThe reaction mixture was purged with nitrogen three times
  2. customA hydrogen balloon was applied to the reaction for three hours
  3. customThe reaction was then purged with N2
  4. filtrationfiltered through Celite
  5. washwashed with EtOH (100 mL)
  6. customSolvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-885d3dc645b0449cbbfffc6d85500b27
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

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