Aluminium lithium hydride → [5-methyl-1-(propan-2-yl)-1H-pyrazol-3-yl]methanol

HRID 706548

反応式

HRID 706548 の反応式
[CH:1]([N:4]1[C:8]([CH3:9])=[CH:7][C:6]([C:10](OCC)=[O:11])=[N:5]1)([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:1]([N:4]1[C:8]([CH3:9])=[CH:7][C:6]([CH2:10][OH:11])=[N:5]1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 23005696Ethyl 1-isopropyl-5-methyl-1H-pyrazole-3-carboxylate

生成物 1

HCID 23005569[5-methyl-1-(propan-2-yl)-1H-pyrazol-3-yl]methanol収率 88%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To ethyl 1-isopropyl-5-methyl-1H-pyrazole-3-carboxylate (7.68 g, 39.1 mmol) in THF (50 mL) at 0° C. was added LAH (1.49 g, 39.1 mmol). The cold bath was removed, and the reaction mixture was stirred for 2 hours, and then quenched carefully with sodium sulfate decahydrate. The reaction mixture was filtered through Celite and washed with Et2O. The filtrate was concentrated under reduced pressure to give 5.3 g (88%) of the title compound.

後処理

  1. customThe cold bath was removed
  2. customquenched carefully with sodium sulfate decahydrate
  3. filtrationThe reaction mixture was filtered through Celite
  4. washwashed with Et2O
  5. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-eddea3fe6be443afb27ba168522ac205
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

関連ノート

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