HCID 67976203、化合物 → HCID 67976239、化合物

HRID 706568ノート

反応式

HRID 706568 の反応式
[CH:1]1([C:6]2[N:11]=[C:10]([CH2:12][N:13]3[C:21]4[C:16](=[C:17]([N+:22]([O-])=O)[CH:18]=[CH:19][CH:20]=4)[C:15]([CH3:25])=[N:14]3)[CH:9]=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>CO.[OH-].[OH-].[Pd+2]>[CH:1]1([C:6]2[N:11]=[C:10]([CH2:12][N:13]3[C:21]4[CH:20]=[CH:19][CH:18]=[C:17]([NH2:22])[C:16]=4[C:15]([CH3:25])=[N:14]3)[CH:9]=[CH:8][CH:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

4

反応物 1

HCID 67976203HCID 67976203、化合物

生成物 1

HCID 67976239HCID 67976239、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

1-((6-cyclopentylpyridin-2-yl)methyl)-3-methyl-4-nitro-1H-indazole (0.470 g, 1.40 mmol) was dissolved in 14 mL of methanol. To this solution was added 20% Pd(OH)2 (0.470 g, 50% water content) and the reaction mixture was stirred under a hydrogen balloon for 2 hours. This mixture was filtered through GF/F filter paper and the filtrate was concentrated to 0.340 g (79%) of the title compound.

後処理

  1. filtrationThis mixture was filtered through GF/F
  2. filtrationfilter paper
  3. concentrationthe filtrate was concentrated to 0.340 g (79%) of the title compound

出典と根拠

ORDレコード
ord-fc3f52bfa6bd4c1e8df06ce0f83acc21
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

読み込み中…