N-bromobutanimide → HCID 178498689、化合物

HRID 706581ノート

反応式

HRID 706581 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:6]2[CH:7]=[N:8][NH:9][C:10]=2[CH:11]=[CH:12][C:13]=1[F:14])=[O:4].[Br:15]N1C(=O)CCC1=O>CN(C=O)C>[Br:15][C:7]1[C:6]2[C:5]([C:3]([O:2][CH3:1])=[O:4])=[C:13]([F:14])[CH:12]=[CH:11][C:10]=2[NH:9][N:8]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 593345601383474-59-6

生成物 1

HCID 178498689HCID 178498689、化合物収率 69%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of methyl-5-fluoro-1H-indazole-4-carboxylate (0.475 g, 2.45 mmol) in 25 mL of DMF was added N-bromosuccinimide (0.566 g, 3.18 mmol). This mixture was stirred at ambient temperature for one hour, then quenched with water. This mixture was extracted with EtOAc, and the combined organic extracts washed with brine, dried over sodium sulfate and concentrated under reduced pressure. Column chromatography (1:1 EtOAc/Hexane) afforded 0.459 g (69%) of the title compound.

後処理

  1. customquenched with water
  2. extractionThis mixture was extracted with EtOAc
  3. washthe combined organic extracts washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-acba70997fb7495e8c4fe10424b11020
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

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