Thionyl Chloride → 3-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride

HRID 706589ノート

反応式

HRID 706589 の反応式
[CH:1]([N:4]1[CH:8]=[CH:7][C:6]([CH2:9]O)=[N:5]1)([CH3:3])[CH3:2].O=S(Cl)[Cl:13]>ClCCl>[ClH:13].[Cl:13][CH2:9][C:6]1[CH:7]=[CH:8][N:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 23005538(1-(propan-2-yl)-1H-pyrazol-3-yl)methanol

生成物 1

HCID 672599053-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(1-Isopropyl-1H-pyrazol-3-yl)methanol was dissolved into dichloromethane and SOCl2 (2 equivalents) was added. The resulting mixture was allowed to stir overnight, then concentrated under vacuum to yield the desired compound (quantitative yield).

後処理

  1. additionwas added
  2. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-10872e3fca3641fa9c11700198ecd3cd
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

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