Ethanol → 7-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid

HRID 706618ノート

反応式

HRID 706618 の反応式
[F:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([O:13]CC)=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1.O1CCCC1.C(O)C.O.[OH-].[Li+]>O>[F:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1

参加物

6

反応物 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 67259301Ethyl 7-fluoroimidazo[1,2-a]pyridine-3-carboxylate

生成物 1

HCID 672607377-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid収率 78.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Ethyl 7-fluoroimidazo[1,2-a]pyridine-3-carboxylate (8 g; 44.4 mmol) was mixed with tetrahydrofuran (225 mL), ethanol (110 mL) and water (55 mL). Lithium hydroxide monohydrate (0.962 g; 22.9 mmol) was added. The mixture was stirred at ambient temperature overnight. The mixture concentrated under reduced pressure to remove tetrahydrofuran and ethanol. Hydrochloric acid (2N) was added to aqueous mixture to adjust to pH 3. White precipitate formed and was filtered off with drying under high vacuum overnight to give 7-fluoroimidazo[1,2-a]pyridine-3-carboxylic acid as a white solid (6.3 g).

後処理

  1. concentrationThe mixture concentrated under reduced pressure
  2. customto remove tetrahydrofuran and ethanol
  3. additionHydrochloric acid (2N) was added to aqueous mixture
  4. customWhite precipitate
  5. customformed
  6. filtrationwas filtered off
  7. customwith drying under high vacuum overnight

出典と根拠

ORDレコード
ord-fb270e9640ee40cd8b25ad7c04376fb6
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

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