Ammonium Chloride → HCID 67974138、化合物

HRID 706645ノート

反応式

HRID 706645 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[C:12]([N+:17]([O-])=O)[CH:13]=[CH:14][CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+]>[Fe].CCO.O>[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:17])[C:11]=2[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 679761361-benzyl-3-methyl-4-nitro-1H-indazole

生成物 1

HCID 67974138HCID 67974138、化合物収率 1,020.3%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 19096565Water ethanol溶媒

実験手順

A solution of 1-benzyl-3-methyl-4-nitro-1H-indazole (0.052 g, 0.19 mmol), ammonium chloride (0.0052 g, 0.097 mmol) in 4:1 EtOH/water (5 mL) was treated with iron (0.11 g, 1.9 mmol) and refluxed for 2 hours. The mixture was concentrated and residue shaken in EtOAc/water, filtered through GF/F paper, and concentrated to provide 1-benzyl-3-methyl-1H-indazol-4-amine (0.46 g, 82% yield) as a yellow gum.

後処理

  1. temperaturerefluxed for 2 hours
  2. concentrationThe mixture was concentrated
  3. filtrationfiltered through GF/F paper
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-8af751a424724879a959b39aa23e4079
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

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