3-methyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole → 3-methyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine

HRID 706660

反応式

HRID 706660 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-])=O)[N:4]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[N:16]=2)[N:3]=1>CCO.[OH-].[OH-].[Pd+2]>[CH3:1][C:2]1[C:10]2[C:9]([NH2:11])=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[N:16]=2)[N:3]=1

参加物

4

反応物 1

HCID 672592993-methyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole

生成物 1

HCID 672609383-methyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine収率 75.1%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A suspension of 3-methyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole (54 mg, 0.19 mmol) in absolute EtOH (1.5 mL) was treated at ambient temperature with 10% palladium hydroxide on carbon (27 mg, 0.019 mmol). The mixture was stirred at ambient temperature under a hydrogen atmosphere for 16 hours, and then filtered through a Celite® pad, washing with EtOH. The filtrate was concentrated under reduced pressure to afford the product (36 mg) as a yellow oil.

後処理

  1. filtrationfiltered through a Celite® pad
  2. washwashing with EtOH
  3. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ccd8ef8d898f4478bffd9b68217a7e77
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

関連ノート

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