Ethyl 6-(prop-1-en-2-yl)picolinate → Ethyl 6-isopropylpicolinate

HRID 706723ノート

反応式

HRID 706723 の反応式
[CH2:1]=[C:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)[CH3:3]>CCO.[Pd]>[CH:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:1]

参加物

4

反応物 1

HCID 67974687Ethyl 6-(prop-1-en-2-yl)picolinate

生成物 1

HCID 67974663Ethyl 6-isopropylpicolinate収率 93%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen and hydrogen three times each. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with nitrogen, filtered through Celite® and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give the desired product (93%).

後処理

  1. customThe reaction mixture was purged with nitrogen and hydrogen three times each
  2. customA hydrogen balloon was applied to the reaction for three hours
  3. customThe reaction was then purged with nitrogen
  4. filtrationfiltered through Celite®
  5. washwashed with EtOH (100 mL)
  6. customSolvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a60ecab01f16470b85fe20fcb765939a
出典データセット
uspto-grants-2015_11
特許番号
US09174981B2

反応ノート

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