Water → 6-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([O:13]CC)=[O:12])=[CH:9][N:10]=2)[CH:7]=1.O.[OH-].[Li+].O.C1COCC1>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=2)[CH:7]=1参加物
6
反応条件
- 温度
- 65 °C
実験手順
Ethyl 6-fluoroimidazo[1,2-a]pyridine-3-carboxylate (0.10 g, 0.48 mmol) and lithium hydroxide monohydrate (0.020 g, 0.48 mmol) were added to a mixture of water, THF and ethanol (1:2:1) and heated in a sealed vial at 65° C. for 6 hours. The solvent was removed by rotary evaporation to yield 87 mg of the desired product. MS (ES+APCI) m/z=181.1 (M+H).
後処理
- customThe solvent was removed by rotary evaporation
出典と根拠
- ORDレコード
- ord-d9a8e9c6dd164383b77d8541e4a5cd4e
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09174981B2
反応ノート
読み込み中…