(2-Amino-4-chlorophenyl)methanol → 2-Amino-4-chlorobenzaldehyde

HRID 707218ノート

反応式

HRID 707218 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]

参加物

4

反応物 1

HCID 4134900(2-Amino-4-chlorophenyl)methanol

生成物 1

HCID 112521382-Amino-4-chlorobenzaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

(2-amino-4-chlorophenyl)methanol (10.08 g, 64.0 mmol) was suspended in chloroform (250 mL) and treated with manganese dioxide (15.87 g, 183 mmol). The mixture was stirred vigorously and heated at reflux. The oxidation was followed by TLC and found to be complete after 1 hour. The suspension was filtered through a pad of CELITE™ and evaporated to dryness under reduced pressure. Further drying under high vacuum gave a dark red solid which was used in the next step without further purification.

後処理

  1. temperatureheated
  2. temperatureat reflux
  3. filtrationThe suspension was filtered through a pad of CELITE™
  4. customevaporated to dryness under reduced pressure
  5. customFurther drying under high vacuum
  6. customgave a dark red solid which
  7. customwas used in the next step without further purification

出典と根拠

ORDレコード
ord-2cf16fb38d554c9fa404efcf50bdba68
出典データセット
uspto-grants-2015_11
特許番号
US09174992B2

反応ノート

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