3-(benzylamino)-N-methoxy-N-methylcyclobutanecarboxamide → 3-amino-N-methoxy-N-methylcyclobutanecarboxamide
反応式
C([NH:8][CH:9]1[CH2:12][CH:11]([C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])[CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[NH2:8][CH:9]1[CH2:12][CH:11]([C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])[CH2:10]1参加物
4
実験手順
A mixture of 3-(benzylamino)-N-methoxy-N-methylcyclobutanecarboxamide (349 mg, 2.2 mmol) and wet palladium hydroxide on activated carbon (50 wt %, 200 mg) in methanol (30 mL) was stirred under hydrogen (30 psi) at room temperature for 13 hours then the reaction mixture was filtered through CELITE™ H and washed with methanol. The filtrate was concentrated in vacuo to give 3-amino-N-methoxy-N-methylcyclobutanecarboxamide (332 mg, 2.09 mmol, yield 95%).
後処理
- filtrationthe reaction mixture was filtered through CELITE™ H
- washwashed with methanol
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-84ee059200d14a1abd932bf47428ff73
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09174992B2
反応ノート
読み込み中…