Dimethylformamide → HCID 71268660、化合物

HRID 70785ノート

反応式

HRID 70785 の反応式
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].CN(C=O)C.Cl.[CH3:21][C:22]1([C:28]([NH2:30])=[O:29])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CCOC(C)=O.O>[CH2:1]([N:25]1[CH2:26][CH2:27][C:22]([CH3:21])([C:28]([NH2:30])=[O:29])[CH2:23][CH2:24]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 6228DimethylformamideHCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 675063694-Methyl-piperidine-4-carboxylic acid aMide hydrochloride

生成物 1

HCID 71268660HCID 71268660、化合物収率 97.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Benzyl chloride (1.90 g) and sodium carbonate (1.59 g) were added to a DMF (70 ml) suspension of 4-methylpiperidine-4-carboxamide hydrochloride (2.24 g), and stirring was performed at room temperature for 16 hours. After adding water to the reaction liquid, extraction was performed with EtOAc. The organic layer was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (MeOH/chloroform) to obtain 1-benzyl-4-methylpiperidine-4-carboxamide (2.85 g).

後処理

  1. customto the reaction liquid, extraction
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (MeOH/chloroform)

出典と根拠

ORDレコード
ord-7dc46dc1d2794a90b2f0c8c24f019f0b
出典データセット
uspto-grants-2014_09
特許番号
US08822688B2

反応ノート

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