Chlorotrimethylsilane → HCID 178452187、化合物

HRID 708270ノート

反応式

HRID 708270 の反応式
[Zn:1].Cl[Si](C)(C)C.BrCCBr.[I:11][CH:12]1[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13]1>CN(C)C(=O)C>[I-:11].[C:19]([O:18][C:16]([N:14]1[CH2:15][CH:12]([Zn+:1])[CH2:13]1)=[O:17])([CH3:22])([CH3:21])[CH3:20]

参加物

6

反応物 4

HCID 6397ChlorotrimethylsilaneHCID 78391,2-DibromoethaneHCID 23994ZincHCID 11000522Tert-butyl 3-iodoazetidine-1-carboxylate

生成物 1

HCID 178452187HCID 178452187、化合物

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒2 回

実験手順

Zinc (2.472 g, 0.03780 mol) was stirred in 10 mL of degassed N,N-dimethylacetamide under N2 atmosphere. Chlorotrimethylsilane (0.411 mL, 0.00324 mol) and 1,2-Dibromoethane (0.233 mL, 0.00270 mol) were added and the mixture was stirred for 20 minutes. Tert-butyl 3-iodoazetidine-1-carboxylate (7.644 g, 0.02700 mol) in degassed N,N-dimethylacetamide (60.0 mL) was added slowly and the cloudy reaction was stirred at room temperature for 1.5 hours to give (1-(tert-butoxycarbonyl)azetidin-3-yl)zinc(II) iodide.

後処理

  1. customthe cloudy reaction
  2. stirringwas stirred at room temperature for 1.5 hours

出典と根拠

ORDレコード
ord-3379675bb8cf46e78f328747ff03c638
出典データセット
uspto-grants-2015_11
特許番号
US09175009B2

反応ノート

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