Sodium Hydroxide → HCID 178524643、化合物

HRID 70898ノート

反応式

HRID 70898 の反応式
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9]C)=[O:8])[S:4][N:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[S:4][N:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178498604HCID 178498604、化合物

生成物 1

HCID 178524643HCID 178524643、化合物収率 99.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl 3-hydroxyisothiazole-5-carboxylate (300 mg, 1.73 mmol) in MeOH (2 mL) is added 1N NaOH (6 mL, 6 mmol). After stirring at room temperature for 2 hours, the crude is concentrated under reduced pressure to remove MeOH and is diluted with EtOAc. The organic layer is washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to give 3-hydroxyisothiazole-5-carboxylic acid (250 mg).

後処理

  1. concentrationthe crude is concentrated under reduced pressure
  2. customto remove MeOH
  3. additionis diluted with EtOAc
  4. washThe organic layer is washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-678f4bf1923a48c7820e53ed6a2bdcf2
出典データセット
uspto-grants-2014_09
特許番号
US08822534B2

反応ノート

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