Ethyl 3-(3-(benzyloxy)-4-methylphenyl)acrylate → Ethyl 3-(3-hydroxy-4-methylphenyl)propanoate

HRID 709661ノート

反応式

HRID 709661 の反応式
C([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:12]=[CH:13][C:14]=1[CH3:15])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:12]=[CH:13][C:14]=1[CH3:15]

参加物

4

反応物 1

HCID 131733900Ethyl 3-(3-(benzyloxy)-4-methylphenyl)acrylate

生成物 1

HCID 117759964Ethyl 3-(3-hydroxy-4-methylphenyl)propanoate収率 85.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 3-(3-(benzyloxy)-4-methylphenyl)acrylate (2.50 g) in ethanol (50 mL) was added 10% palladium-activated carbon (250 mg) and, under a hydrogen atmosphere, the mixture was stirred at room temperature for 15 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.50 g) as a colorless oil.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-fe54c0b0165c40e18d6f230120a55172
出典データセット
uspto-grants-2015_11
特許番号
US09181186B2

反応ノート

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