Ethyl 3-(2-fluoro-5-methoxyphenyl)acrylate → Ethyl 3-(2'-fluoro-5'-methoxyphenyl)propionate
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>C(O)C.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]参加物
4
実験手順
To a solution of ethyl 3-(2-fluoro-5-methoxyphenyl)acrylate (224 mg) in ethanol (50 mL) was added 10% palladium-activated carbon (24 mg), and the mixture was stirred for 15 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (208 mg) as a colorless oil. This compound was used for the next step without further purification.
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-80a7e8a5ed1347578799d212686ee9f3
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181186B2
反応ノート
読み込み中…