Nitric Acid → 3,5-Dichloro-2-nitrobenzaldehyde

HRID 70979ノート

反応式

HRID 70979 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH:5]=[O:6].[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([N+:11]([O-:13])=[O:12])=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH:5]=[O:6]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 357463,5-Dichlorobenzaldehyde

生成物 1

HCID 27504943,5-Dichloro-2-nitrobenzaldehyde収率 79%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

2-Amino-3-(5,7-dichloro-3-methoxy-2H-indazol-2-yl)-2-methylpropionitrile was prepared using a procedure similar to that described in Example 1, part b, except starting from 1-(5,7-dichloro-3-methoxy-2H-indazol-2-yl)propan-2-one. 1-(4,6-dichloro-3-methoxy-2H-indazol-2-yl)propan-2-one was prepared using a procedure similar to that described in Example 105 part a to d except using 3,5-dichloro-2-nitrobenzaldehyde (2.1 g) and decaborane (0.41 g) in part a to yield [2-(tert-butyldimethylsilanyloxy)propyl]-(3,5-dichloro-2-nitrobenzyl)amine (1.2 g, 32%). 3,5-Dichloro-2-nitrobenzaldehyde (2.2 g, 79%) was prepared by nitration of 3,5-dichlorobenzaldehyde (2.2 g) in a mixture of nitric acid (1.5 mL) and sulfuric acid (8 mL) at 0° C. for 30 minutes.

出典と根拠

ORDレコード
ord-f24ef27b071d49dc8da1449f0608ab2c
出典データセット
uspto-grants-2014_09
特許番号
US08822689B2

反応ノート

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