Hydrazine hydrate (1:1) → HCID 86706769、化合物

HRID 710056ノート

反応式

HRID 710056 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[O:6][CH2:7][C:8](=O)[C:9]#[C:10][C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17].O.[NH2:30][NH2:31]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[O:6][CH2:7][C:8]1[NH:31][N:30]=[C:10]([C@@H:11]2[CH2:15][CH2:14][CH2:13][N:12]2[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:9]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 86706767(S)-t-Butyl 2-(4-(3,4-dimethoxyphenoxy)-3-oxobut-1-yn-1-yl)pyrrolidine-1-carboxylate

生成物 1

HCID 86706769HCID 86706769、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To an EtOH (10 mL) solution of the compound (395 mg) obtained in Example 14-(2), hydrazine hydrate (63 μL) was added and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated, water (50 mL) was added, and the organic layer extracted with AcOEt (50 mL) was dried (MgSO4), filtered and concentrated to give the titled compound (466 mg, pale brown amorphous.)

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionwater (50 mL) was added
  3. extractionthe organic layer extracted with AcOEt (50 mL)
  4. dry with materialwas dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-c08d4483652d4d1d99966dd5073ace3a
出典データセット
uspto-grants-2015_11
特許番号
US09181229B2

反応ノート

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