Hydrochloric Acid → 1-Amino-3-(3,4-dimethoxyphenoxy)propan-2-one hydrochloride

HRID 710062ノート

反応式

HRID 710062 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[O:6][CH2:7][C:8](=[O:13])[CH2:9][N+:10]([O-])=O.[ClH:19].[H][H]>[Pd].CO>[ClH:19].[NH2:10][CH2:9][C:8](=[O:13])[CH2:7][O:6][C:5]1[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:3]([O:2][CH3:1])[CH:4]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 867067741-(3,4-Dimethoxyphenoxy)-3-nitropropan-2-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 867067751-Amino-3-(3,4-dimethoxyphenoxy)propan-2-one hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a MeOH (7 ml) solution of the compound (0.660 g) obtained in Example 19-(2), 10% Pd—C (0.330 g) and an aqueous solution of 1N HCl (14 ml) were added and the mixture was stirred at room temperature for 5 hours in a hydrogen gas atmosphere. The insoluble matter was filtered off and the filtrate was concentrated to give the titled compound (0.715 g, brown amorphous.)

後処理

  1. filtrationThe insoluble matter was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-0343177e56eb4de2aea60c267dd6a7c7
出典データセット
uspto-grants-2015_11
特許番号
US09181229B2

反応ノート

読み込み中…