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HRID 710195作成日：2026年10月25日

5-(But-2-ynyloxy)pyrazine-2-carboxylic acid → 5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((4S,4aR,7aR)-2-amino-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/710195

反応式

関与物質

役割名称HCID仕込み量
反応物5-(But-2-ynyloxy)pyrazine-2-carboxylic acidHCID 58448677—
反応物(4S,4aR,7aR)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-2-ylamineHCID 90021263—
生成物5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((4S,4aR,7aR)-2-amino-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 72706009—

反応手順

The coupling of (4S,4aR,7aR)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-2-ylamine (intermediate XIIIa-1) and 5-but-2-ynyloxy-pyrazine-2-carboxylic acid (CAS 1221447-98-814) following procedure Q yielded the title compound as an amorphous colorless material (34% yield). MS: m/z=474.2 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09181232B2
出典データセットuspto-grants-2015_11
ORD IDord-977f30d217fb42f19353fb3224212237
出典メモuspto-grants-2015_11