Trifluoroacetic acid → N-((R)-1-(4-Fluorophenyl)-2-hydroxyethyl)-4-((S)-morpholin-2-yl)benzamide

HRID 710257ノート

反応式

HRID 710257 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([C@@H:20]3[O:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]3)=[CH:16][CH:15]=2)=[O:13])[CH2:9][OH:10])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:11][C:12](=[O:13])[C:14]2[CH:19]=[CH:18][C:17]([C@@H:20]3[O:25][CH2:24][CH2:23][NH:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:9][OH:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 89689438HCID 89689438、化合物

生成物 1

HCID 89689472N-((R)-1-(4-Fluorophenyl)-2-hydroxyethyl)-4-((S)-morpholin-2-yl)benzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate (44 mg, 0.099 mmol) was dissolved in dichloromethane (0.3 ml) and trifluoracetic acid (447 mg, 0.3 ml, 3.92 mmol) was added. The reaction mixture was stirred at room temperature for 60 min. The solvent and excess of trifluoracetic acid were evaporated. The residue was dissolved in dichloromethane (3 ml) and extracted with odium bicarbonate saturated solution (2 ml). The organic layer was dried over MgSO4 and evaporated. The crude product was directly used for the next step.

後処理

  1. customThe solvent and excess of trifluoracetic acid were evaporated
  2. dissolutionThe residue was dissolved in dichloromethane (3 ml)
  3. extractionextracted with odium bicarbonate saturated solution (2 ml)
  4. dry with materialThe organic layer was dried over MgSO4
  5. customevaporated

出典と根拠

ORDレコード
ord-8e991b8a49ac4ae1b636bb15359c4856
出典データセット
uspto-grants-2015_11
特許番号
US09181230B2

反応ノート

読み込み中…