4-Hydroxybenzaldehyde → 3,5-Dichloro-4-propoxybenzaldehyde

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:11])[C:9]=1[OH:10])[CH:5]=[O:6].O[C:13]1[CH:20]=CC(C=O)=C[CH:14]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:11])[C:9]=1[O:10][CH2:14][CH2:13][CH3:20])[CH:5]=[O:6]

参加物

反応物 2

HCID 1264-Hydroxybenzaldehyde

HCID 168393,5-Dichloro-4-hydroxybenzaldehyde

生成物 1

HCID 47701453,5-Dichloro-4-propoxybenzaldehyde収率 94%

実験手順

When 3,5-dichloro-4-hydroxybenzaldehyde was substituted for 4-hydroxy-benzaldehyde in Example 50, Step A the similar procedure afforded the title compound in 94% yield, as pale oil. 1H-NMR (CDCl3) 1.1 (tr, 3H, J=7.41 Hz); 1.82-1.93 (m, 2H); 4.04 (tr, 2H, J=6.54 Hz); 7.8 (s 2H); 9.84 (s, 1H).

出典と根拠

ORDレコード: ord-6cd9c91f4157463da5b8ead4a0fd2b1d
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09181182B2

反応ノート

読み込み中…