反応式
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]#[C:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][CH:21]=[CH:20]3)=[CH:11][CH:10]=1>CCO.[Pd]>[F:27][C:2]([F:1])([F:26])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][CH:21]=[CH:20]3)=[CH:13][CH:14]=1参加物
4
実験手順
A suspension of the product of Step B (0.25 g, 0.7 mmol) and 10% Pd/C (0.1 g) in EtOH (10 ml) was stirred overnight under H2. The mixture was filtered through Celite bead and the filtrate was evaporated to dryness to give the desired product (0.25 g, 98%) as pale paste. 1H-NMR (CDCl3) 2.97-3.1 (m, 4H); 6.5 (m, 1H); 7.04 (dd, 1H, J=1.37, 8.3 Hz), 7.15-7.2 (m, 2H); 7.30-7.34 (m, 2H); 7.37-7.44 (m, 2H); 7.51 (d, 1H, J=7.56 Hz); 8.68 (broad s, 1H).
後処理
- filtrationThe mixture was filtered through Celite bead
- customthe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-168060126ce04fa8bc8df16de9f7b969
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181182B2
関連ノート
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