Potassium Carbonate → HCID 178513240、化合物
反応式
[C:1]([C:3]1[CH:11]=[CH:10][C:6]2[N:7]=[CH:8][NH:9][C:5]=2[CH:4]=1)#[N:2].C([O-])([O-])=O.[K+].[K+].Cl.[NH2:19][OH:20]>CCO.CCOCC>[OH:20][NH:19][C:1]([C:3]1[CH:11]=[CH:10][C:6]2[NH:7][CH:8]=[N:9][C:5]=2[CH:4]=1)=[NH:2]参加物
6
実験手順
A solution of 5-cyanobenzimidazole (1.43 g; 10 mmol; 1 eq.) in EtOH (30 ml) was treated with K2CO3 (2.76 g; 20 mmol; 2 eq.) and hydroxylaminehydrochloride (765 mg; 11 mmol; 1.1 eq.) and heated to reflux over night. After cooling to room temperature, the mixture was diluted with Et2O. The resulting solid was collected by filtration, washed with Et2O and water and used without further purification. Yield: 1.28 g (72.7%); MS m/z: 177.3 [M+H]+
後処理
- temperatureheated
- temperatureto reflux over night
- filtrationThe resulting solid was collected by filtration
- washwashed with Et2O and water
- customused without further purification
出典と根拠
- ORDレコード
- ord-bf3b1cccb195437ea40fa5c1bf4a264e
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181233B2
反応ノート
読み込み中…