Hydrogen Bromide → 1-(2-Bromoethyl)-4-chlorobenzene
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[CH3:9])=[CH:4][CH:3]=1.[BrH:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:11])=[CH:4][CH:3]=1参加物
3
実験手順
In a 65 mL glass pressure vessel, 4-chlorophenylethanol (32.725 g, 209 mmol) was warmed to between 90 and 100° C. The vessel was charged with hydrogen bromide gas and the mixture was stirred at +1.38 to +1.93 bar for 4.5 h. The pressure was released and the reaction showed 99.18% conversion by HPLC. The mixture was allowed to cool to room temperature to leave 2-(4-chlorophenyl)ethyl bromide as a brown liquid (53.735 g).
出典と根拠
- ORDレコード
- ord-4d1a51bd11334accb7757aef65b5f025
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822727B2
反応ノート
読み込み中…