Chlorosuccinimide → HCID 178506300、化合物

HRID 710649

反応式

HRID 710649 の反応式
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.C1C(=O)N([Cl:17])C(=O)C1>CC#N>[Cl:17][C:7]1[C:3]([C:2]([F:9])([F:8])[F:1])=[N:4][NH:5][CH:6]=1

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 18070343-(Trifluoromethyl)pyrazole

生成物 1

HCID 178506300HCID 178506300、化合物収率 77%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

A mixture of 3-(trifluoromethyl)pyrazole (1.58 g, 11.6 mmol) and NCS (1.55 g, 11.6 mmol) in CH3CN (20 mL) was heated at 80° C. for 3 hrs. It was then cooled to rt, evaporated in vacuo, and purified by flash chromatography (SiO2) with a gradient elution of 0 to 15% EtOAc/CH2Cl2 to afford 4-chloro-3-(trifluoromethyl)pyrazole (1.52 g, 77%).

後処理

  1. temperatureIt was then cooled to rt
  2. customevaporated in vacuo
  3. custompurified by flash chromatography (SiO2) with a gradient elution of 0 to 15% EtOAc/CH2Cl2

出典と根拠

ORDレコード
ord-68aec33ad7dd4055a0d2ae5214264e52
出典データセット
uspto-grants-2015_11
特許番号
US09181241B2

関連ノート

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