Chlorosuccinimide → (4-chloro-5-methyl-1H-pyrazol-1-yl)acetic acid
反応式
[CH3:1][C:2]1[N:6]([CH2:7][C:8]([OH:10])=[O:9])[N:5]=[CH:4][CH:3]=1.C1C(=O)N([Cl:18])C(=O)C1>CC#N>[Cl:18][C:3]1[CH:4]=[N:5][N:6]([CH2:7][C:8]([OH:10])=[O:9])[C:2]=1[CH3:1]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 2-(5-methylpyrazol-1-yl)acetic acid (0.700 g, 5 mmol) and NCS (0.668 g, 5 mmol) in CH3CN (10 mL) was heated at 80° C. for 1.5 hrs. It was then cooled to rt, evaporated in vacuo, and purified by flash chromatography (SiO2, with a gradient elution of 0-20% MeOH/CH2Cl2) to afford 2-(4-chloro-5-methylpyrazol-1-yl)acetic acid (0.870 g, 100%).
後処理
- temperatureIt was then cooled to rt
- customevaporated in vacuo
- custompurified by flash chromatography (SiO2
- washwith a gradient elution of 0-20% MeOH/CH2Cl2)
出典と根拠
- ORDレコード
- ord-ee7fde86b7ae4cdf8487ad0c7d4a9450
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181241B2
反応ノート
読み込み中…