Ferulic Acid → Sitagliptin Ferulate

HRID 711120

反応式

HRID 711120 の反応式
[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[C:29]([OH:42])(=[O:41])/[CH:30]=[CH:31]/[C:32]1[CH:40]=[CH:39][C:37]([OH:38])=[C:34]([O:35][CH3:36])[CH:33]=1>C(#N)C>[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[C:29]([O-:42])(=[O:41])/[CH:30]=[CH:31]/[C:32]1[CH:40]=[CH:39][C:37]([OH:38])=[C:34]([O:35][CH3:36])[CH:33]=1

参加物

4

反応物 2

HCID 445858Ferulic AcidHCID 4369359Sitagliptin

生成物 1

HCID 178490572Sitagliptin Ferulate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Sitagliptin free base (2.0 gms) and ferulic acid (0.95 gms) were dissolved in acetonitrile (16 ml) at 60° C. to 65° C. and the reaction mass left for slow solvent evaporation at room temperature for 48 hours. Precipitated solids were filtered off and dried at 50° C. to 55° C. for 6 hours to obtain the title compound. Yield: 1.45 gms.

後処理

  1. customPrecipitated solids
  2. filtrationwere filtered off
  3. customdried at 50° C. to 55° C. for 6 hours

出典と根拠

ORDレコード
ord-17157ddc94ba414c843b61589241dabb
出典データセット
uspto-grants-2015_11
特許番号
US09181256B2

関連ノート

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