化工社化工社 化学情報印刷レポート · 研究参考用
P-Coumaric Acid → HCID 178511829、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | P-Coumaric Acid | HCID 637542 | — |
| 反応物 | Sitagliptin | HCID 4369359 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 178511829 | HCID 178511829 | — |
反応手順
Sitagliptin free base (2.0 gms) and coumaric acid (0.80 gms) were dissolved in acetonitrile (15 ml) at 60° C. to 65° C. and cooled the solution to −10° C. to −5° C. over a period of 6 hours. Precipitated solids were filtered and dried at 50° C. to 55° C. for 6 hours to obtain the title compound. Yield: 1.62 gms.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181256B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-2088f85a537b4efd82a5de1bdb5d899c |
| 出典メモ | uspto-grants-2015_11 |