Diisopropyl Ether → HCID 178511829、化合物

HRID 711127

反応式

HRID 711127 の反応式
[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[CH:29]1[C:34](/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38])=[CH:33][CH:32]=[C:31]([OH:40])[CH:30]=1.C(OC(C)C)(C)C>CO>[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[C:37]([O-:39])(=[O:38])/[CH:36]=[CH:35]/[C:34]1[CH:33]=[CH:32][C:31]([OH:40])=[CH:30][CH:29]=1

参加物

5

反応物 3

HCID 7914Diisopropyl EtherHCID 637542P-Coumaric AcidHCID 4369359Sitagliptin

生成物 1

HCID 178511829HCID 178511829、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sitagliptin free base (2.0 gms) and coumaric acid (0.80 gms) were dissolved in methanol (12 ml) at 60° C. to 65° C. and the solution was cooled to room temperature. Isopropyl ether (240 ml) was added to the resultant clear solution and stirred for 14 hours. Precipitated solids were filtered and dried at 50° C. to 55° C. for 6 hours to obtain the title compound.

後処理

  1. customPrecipitated solids
  2. filtrationwere filtered
  3. customdried at 50° C. to 55° C. for 6 hours

出典と根拠

ORDレコード
ord-b433bb3107814315a15bc68ab198b2e5
出典データセット
uspto-grants-2015_11
特許番号
US09181256B2

関連ノート

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