Diisopropyl Ether → HCID 178511829、化合物

HRID 711132

反応式

HRID 711132 の反応式
[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[CH:29]1[C:34](/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38])=[CH:33][CH:32]=[C:31]([OH:40])[CH:30]=1.C(OC(C)C)(C)C>CO>[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[C:37]([O-:39])(=[O:38])/[CH:36]=[CH:35]/[C:34]1[CH:33]=[CH:32][C:31]([OH:40])=[CH:30][CH:29]=1

参加物

5

反応物 3

HCID 7914Diisopropyl EtherHCID 637542P-Coumaric AcidHCID 4369359Sitagliptin

生成物 1

HCID 178511829HCID 178511829、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sitagliptin free base (0.5 gms) and coumaric acid (0.20 gms) were dissolved in methanol (3 ml) at 60° C. to 65° C. and the resultant solution was cooled to room temperature. Isopropyl ether (60 ml) was added to the resultant clear solution and stirred for 2 hours. Precipitated solids were filtered and suck dried for 20 minutes to obtain the title compound. Yield: 0.38 gms.

後処理

  1. customPrecipitated solids
  2. filtrationwere filtered
  3. customsuck dried for 20 minutes

出典と根拠

ORDレコード
ord-4e530492328c4223abc317b527971d30
出典データセット
uspto-grants-2015_11
特許番号
US09181256B2

関連ノート

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