Ammonium → HCID 43528580、化合物

HRID 711219ノート

反応式

HRID 711219 の反応式
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][N:8]=2)[CH2:3][CH2:2]1.[NH4+]>CO.C1COCC1.[Ni]>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:8]=[CH:9][C:10]([CH2:11][NH2:12])=[CH:13][CH:14]=2)[CH2:3][CH2:2]1

参加物

6

反応物 2

HCID 223AmmoniumHCID 28787470HCID 28787470、化合物

生成物 1

HCID 43528580HCID 43528580、化合物

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
35 °C

実験手順

To the solution of 6-thiomorpholinonicotinonitrile 8-3 (1.0 g, 4.8 mmol) in methanol (15 ml) and THF (9 ml) was added Raney-Nickel (0.7 g) and aqueous ammonium (3 mL). The reaction was stirred under hydrogen balloon at 35° C. for 4 hours. After removing the Raney-Nickel by filtering through celite pad, the filtrate was concentrated to give (6-thiomorpholinopyridin-3-yl)methanamine 8-4 as a light green solid. MS m/z 210.1 (M+1).

後処理

  1. customAfter removing the Raney-Nickel
  2. filtrationby filtering through celite pad
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-811cf79bf8094e26a331ae233b98d09c
出典データセット
uspto-grants-2015_11
特許番号
US09181235B2

反応ノート

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