Trifluoroacetic acid → 4-(aminomethyl)-1-(2-(trifluoromethyl)pyridin-4-yl)pyridin-2(1H)-one

HRID 711265ノート

反応式

HRID 711265 の反応式
[O:1]=[C:2]1[CH:7]=[C:6]([CH2:8][NH:9]C(=O)OC(C)(C)C)[CH:5]=[CH:4][N:3]1[C:17]1[CH:22]=[CH:21][N:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:9][CH2:8][C:6]1[CH:5]=[CH:4][N:3]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=2)[C:2](=[O:1])[CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86679722Tert-butyl (2-oxo-1-(2-(trifluoromethyl)pyridin-4-yl)-1,2-dihydropyridin-4-yl)methylcarbamate

生成物 1

HCID 672086134-(aminomethyl)-1-(2-(trifluoromethyl)pyridin-4-yl)pyridin-2(1H)-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To the solution of tert-butyl (2-oxo-1-(2-(trifluoromethyl)pyridin-4-yl)-1,2-dihydropyridin-4-yl)methylcarbamate 56-6 (95 mg, 0.26 mmol) in DCM (2 mL) was added TFA (2 mL) at room temperature. The reaction was stirred at room temperature for 30 minutes. The solvent and TFA was removed by rotary evaporation to give crude 4-(aminomethyl)-1-(2-(trifluoromethyl)pyridin-4-yl)pyridin-2(1H)-one 56-7. MS m/z 270.2 (M+1).

後処理

  1. customThe solvent and TFA was removed by rotary evaporation

出典と根拠

ORDレコード
ord-ada867bbee6241a890a933da014dcd45
出典データセット
uspto-grants-2015_11
特許番号
US09181235B2

反応ノート

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