Lithium Hydroxide → 1-(3-Fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 711279ノート

反応式

HRID 711279 の反応式
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16]C)=[O:15])=[CH:10][C:9]2=[O:18])[CH:5]=[CH:6][CH:7]=1.[Li+].[OH-]>O.CO>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9]2=[O:18])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 68083398HCID 68083398、化合物

生成物 1

HCID 680798531-(3-Fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of methyl 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 89-2 (50 mg, 0.202 mmol) in water (0.5 mL) and methanol (0.5 mL) was added LiOH (20 mg, 0.835 mmol). After stirring at room temperature for 30 minutes, the mixture was concentrated with rotavap and the residue extracted with ethyl acetate, which was then evaporated to give crude 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid 89-3.

後処理

  1. concentrationthe mixture was concentrated with rotavap
  2. extractionthe residue extracted with ethyl acetate, which
  3. customwas then evaporated

出典と根拠

ORDレコード
ord-5e497a2d71234e5a85617351badacf58
出典データセット
uspto-grants-2015_11
特許番号
US09181235B2

反応ノート

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