Formic Acid → Methyl 4-formamido-3-methoxybenzoate

HRID 71135

反応式

HRID 71135 の反応式
[CH:1](O)=[O:2].C(OC(=O)C)(=O)C.[NH2:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=1[O:22][CH3:23]>C1COCC1>[CH:1]([NH:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=1[O:22][CH3:23])=[O:2]

参加物

5

反応物 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 602411Methyl 4-amino-3-methoxybenzoate

生成物 1

HCID 23085082Methyl 4-formamido-3-methoxybenzoate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To formic acid (75 mL) was added dropwise acetic anhydride (50 mL) at room temperature, and the mixture was stirred at room temperature for 40 min. A mixture of methyl 4-amino-3-methoxybenzoate (25 g) in THF (100 mL) was added dropwise to the reaction mixture, and the mixture was stirred at room temperature for 1 hr. Ice water (700 mL) was added to the reaction mixture, and the precipitated solid was collected by filtration. The solid was washed with water (400 mL) to give the title compound (25.8 g).

後処理

  1. additionwas added dropwise to the reaction mixture
  2. stirringthe mixture was stirred at room temperature for 1 hr
  3. filtrationthe precipitated solid was collected by filtration
  4. washThe solid was washed with water (400 mL)

出典と根拠

ORDレコード
ord-da5866695f654abbb84dcf84c965f3f0
出典データセット
uspto-grants-2014_09
特許番号
US08822699B2

関連ノート

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